Det er gjort en rekke kliniske studier på tramadol og de er av varierende kvalitet. I en vurdering fra Statens legemiddelkontroll, mener de at tramadol har effekt ved reasonable smertetilstander, Males sett preparatets bivirkninger i forhold til effekten, anser de ikke tramadol som fileørstevalg i behandling av reasonable smerter (two).Legemiddel

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